BDBM251460 US9452998, 9

SMILES CC1(N)CCN(CC1)c1cccnc1NC(=O)c1nc(cnc1N)-c1ncccc1C(F)(F)F

InChI Key InChIKey=XXJXHXJWQSCNPX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 251460   

TargetProtein kinase C theta type(Human)
Novartis

US Patent
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
US Patent

TargetProtein kinase C theta type(Human)
Novartis

US Patent
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PKA-theta (unknown origin) using Fam-labelled S6-derived peptide incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Novartis

US Patent
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PKCtheta (unknown origin) incubated for 15 mins in presence of 33P-ATP by Topcount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PKC-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 1.90nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
US Patent

TargetProtein kinase C epsilon type(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of PKCepsilon (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C theta type(Human)
Novartis

US Patent
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 3nMAssay Description:Inhibition of PKCtheta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 3nMAssay Description:Inhibition of PKCalpha (unknown origin) incubated for 15 mins in presence of 33P-ATP by Topcount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C delta type(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of PKCdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C eta type(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 13nMAssay Description:Inhibition of PKCeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 25nMAssay Description:Inhibition of PKCalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C beta type(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 58nMAssay Description:Inhibition of PKCbeta2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C beta type(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 66nMAssay Description:Inhibition of PKCbeta1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C gamma type(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 109nMAssay Description:Inhibition of PKCgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Novartis

US Patent
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 3.10E+3nMpH: 7.0 T: 2°CAssay Description:Types of GSK-3 assay used to test the selectivity/off target potential compounds of the invention with respect to PKC ±/ inhibition activity includes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
US Patent

TargetBifunctional peptidase and (3S)-lysyl hydroxylase JMJD7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM251460(US9452998, 9)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of N-terminal His-tagged human JMJD7 (1 to 316 residues) expressed in Escherichia coli BL21 (DE3) luciferase based succinate-gloTM JmjC de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed