BDBM251532 US9452998, 81

SMILES COC1CN(CCC1N)c1cccnc1NC(=O)c1nc(cnc1N)-c1ncccc1OC(F)(F)F

InChI Key InChIKey=MLWUDVHJKVMILP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 251532   

TargetProtein kinase C alpha type(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM251532(US9452998, 81)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PKCalpha (unknown origin) incubated for 15 mins in presence of 33P-ATP by Topcount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C alpha type(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM251532(US9452998, 81)
Affinity DataIC50: 0.360nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
US Patent

TargetProtein kinase C theta type(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM251532(US9452998, 81)
Affinity DataIC50: 18nMAssay Description:Inhibition of PKCtheta (unknown origin) incubated for 15 mins in presence of 33P-ATP by Topcount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C theta type(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM251532(US9452998, 81)
Affinity DataIC50: 19nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
US Patent