BDBM254021 US9701685, 73::racemic 4-{[6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(1-fluoromethyl-cyclopropylmethyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidin]e-5'-carbonyl]-amino}-3-methoxy-benzoic acid methyl ester

SMILES COC(=O)c1ccc(NC(=O)[C@@H]2N[C@@H](CC3(CF)CC3)C3([C@H]2c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc32)c(OC)c1

InChI Key InChIKey=IOAIQZCOATXIRX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 254021   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Hudson Biopharma

US Patent
LigandPNGBDBM254021(racemic 4-{[6-chloro-4'-(3-chloro-2-fluoro-phenyl)...)
Affinity DataIC50: 7.20nMpH: 7.4 T: 2°CAssay Description:Test compounds (12.34 uM stock in DMSO) were diluted three fold in series in DMSO and 2 ul per well were added into 384-well polypropylene plates (Ma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent