BDBM254899 US9493472, 21

SMILES COc1cc(cc2nc(N[C@H](CF)c3cccc(Cl)c3)oc12)C(=O)N1CC(C)OCC1C1CC(O)C1

InChI Key InChIKey=OAZBEQQNMLSDQD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 254899   

TargetThyroid hormone receptor beta(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM254899(US9493472, 21)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of purified human plasma thrombin using Boc-Asp(OBzl)-Pro-Arg-AMC substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetProthrombin(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM254899(US9493472, 21)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:To determine the thrombin inhibition of the substances listed above, a biochemical test system is constructed in which the conversion of a thrombin s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
US Patent