BDBM255004 US9475813, 9

SMILES O=C1N(CN([C@H]2CC[C@H](CNCC#N)CC2)c2c1cnc1[nH]ccc21)C1CC1

InChI Key InChIKey=RSSBOIKGTPEZTD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 255004   

TargetTyrosine-protein kinase JAK1(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM255004(US9475813, 9)
Affinity DataIC50: 3.40nMAssay Description:The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM255004(US9475813, 9)
Affinity DataIC50: 17nMAssay Description:The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM255004(US9475813, 9)
Affinity DataIC50: 33nMAssay Description:The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM255004(US9475813, 9)
Affinity DataIC50: 110nMAssay Description:The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent