BDBM255039 US9475813, 60

SMILES FC(F)CNC[C@H]1CC[C@@H](CC1)N1CN(CC#N)C(=O)c2cnc3[nH]ccc3c12

InChI Key InChIKey=OWZUPJBYJRUXLY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 255039   

TargetTyrosine-protein kinase JAK1(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM255039(US9475813, 60)
Affinity DataIC50: 2.70nMAssay Description:The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM255039(US9475813, 60)
Affinity DataIC50: 29nMAssay Description:The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM255039(US9475813, 60)
Affinity DataIC50: 41nMAssay Description:The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM255039(US9475813, 60)
Affinity DataIC50: 54nMAssay Description:The inhibitory activity of the compounds of the present invention against JAK was measured.The respective enzymes (JAK1, JAK2, JAK3 and Tyk2) were pu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent