BDBM255256 US9481682, 4

SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CC[C@H]2CCC(=O)N2C1

InChI Key InChIKey=SRSQULBCTWSVKL-MJGOQNOKSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 255256   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  0.100nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase Yes(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  12nMAssay Description:Inhibition of YES1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with goat anti-hu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  24nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with anti-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  11nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  162nMAssay Description:Inhibition of CSK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  24nMAssay Description:Inhibition of ERBB4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  34nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  87nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  20nMAssay Description:Inhibition of LYNB (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  42nMAssay Description:Inhibition of PTK6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  33nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Srms(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  63nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase TXK(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  33nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255256(US9481682, 4)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant full length BTK (unknown origin) expressed in baculovirus infected Sf9 cells using Biotin-EQEDEPEGDYFEWLE-NH2 peptide as su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed