BDBM25561 2,6-Disubstituted Pyrazine, 1::CHEMBL200114::N-(3-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}phenyl)acetamide

SMILES COc1cc(Nc2cncc(n2)-c2cccc(NC(C)=O)c2)cc(OC)c1OC

InChI Key InChIKey=XHHWYSOCWRJUGN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 25561   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25561(2,6-Disubstituted Pyrazine, 1 | CHEMBL200114 | N-(...)
Affinity DataIC50:  3.50E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25561(2,6-Disubstituted Pyrazine, 1 | CHEMBL200114 | N-(...)
Affinity DataIC50:  3.60E+3nMAssay Description:Growth inhibition in human melanoma cells WM266.4 expressing mutant B-RAF with SRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM25561(2,6-Disubstituted Pyrazine, 1 | CHEMBL200114 | N-(...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibitory activity against human B-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed