BDBM25585 2,6-Disubstituted Pyrazine, 30::6-(naphthalen-1-ylsulfanyl)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine

SMILES COc1cc(Nc2cncc(Sc3cccc4ccccc34)n2)cc(OC)c1OC

InChI Key InChIKey=BDJYSNDBFUBGRJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25585   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25585(6-(naphthalen-1-ylsulfanyl)-N-(3,4,5-trimethoxyphe...)
Affinity DataIC50: 9.80E+3nMpH: 7.2 T: 2°CAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed