BDBM256012 US9481672, 190

SMILES CN1c2ccc(cc2OC1=O)N3C=C(C(=O)N(C3=O)[C@@H]4CCc5c4cccc5C(F)(F)F)C(=O)O

InChI Key InChIKey=JDARDSVOVYVQST-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 256012   

Targetchymase(Golden hamster)TBA
LigandPNGBDBM256012(US9481672, 190 | US20250302837, Example fulacimsta...)
Affinity DataIC50: 3nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetChymase(Human)TBA
LigandPNGBDBM256012(US9481672, 190 | US20250302837, Example fulacimsta...)
Affinity DataIC50: 4nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetCathepsin G(Human)TBA
LigandPNGBDBM256012(US9481672, 190 | US20250302837, Example fulacimsta...)
Affinity DataIC50: 140nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

Targetchymase(Golden hamster)TBA
LigandPNGBDBM256012(US9481672, 190 | US20250302837, Example fulacimsta...)
Affinity DataIC50: 140nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetCoagulation factor X(Human)TBA
LigandPNGBDBM256012(US9481672, 190 | US20250302837, Example fulacimsta...)
Affinity DataIC50: 1.50E+4nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM256012(US9481672, 190 | US20250302837, Example fulacimsta...)
Affinity DataIC50: 1.50E+4nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetSerine protease 1(Human)TBA
LigandPNGBDBM256012(US9481672, 190 | US20250302837, Example fulacimsta...)
Affinity DataIC50: 1.50E+4nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetProthrombin(Human)TBA
LigandPNGBDBM256012(US9481672, 190 | US20250302837, Example fulacimsta...)
Affinity DataIC50: 1.50E+4nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetCoagulation factor XI(Human)TBA
LigandPNGBDBM256012(US9481672, 190 | US20250302837, Example fulacimsta...)
Affinity DataIC50: 1.50E+4nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetPlasma kallikrein(Human)TBA
LigandPNGBDBM256012(US9481672, 190 | US20250302837, Example fulacimsta...)
Affinity DataIC50: 1.50E+4nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetPlasminogen(Human)TBA
LigandPNGBDBM256012(US9481672, 190 | US20250302837, Example fulacimsta...)
Affinity DataIC50: 1.50E+4nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged tracer bound to B-Raf via TR-FRET from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent