BDBM2590 (Arylindolyl)maleimide deriv. 12::3-(1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::ROCHE screening, 40::bis-indolylmaleimide deriv. 8g

SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12

InChI Key InChIKey=SEAKDKTVXBDRHV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 2590   

TargetProtein kinase C beta type(Rat)
Roche Products

LigandPNGBDBM2590(bis-indolylmaleimide deriv. 8g | 3-(1H-indol-3-yl)...)
Affinity DataIC50: 220nMpH: 7.5 T: 2°CAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2004
Entry Details Article
PubMed
LigandPNGBDBM2590(bis-indolylmaleimide deriv. 8g | 3-(1H-indol-3-yl)...)
Affinity DataIC50: 1.25E+3nMpH: 7.0 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandPNGBDBM2590(bis-indolylmaleimide deriv. 8g | 3-(1H-indol-3-yl)...)
Affinity DataIC50: 1.95E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Technical University of Dortmund

LigandPNGBDBM2590(bis-indolylmaleimide deriv. 8g | 3-(1H-indol-3-yl)...)
Affinity DataIC50: 2.69E+3nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2015
Entry Details Article
PubMed
LigandPNGBDBM2590(bis-indolylmaleimide deriv. 8g | 3-(1H-indol-3-yl)...)
Affinity DataIC50: 1.17E+4nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed