BDBM259337 US9505745, 14::US9790212, Example 14

SMILES CCN(c1c(C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)nn1C)C1CCOCC1

InChI Key InChIKey=IESJTEZXBWQDBI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 259337   

LigandChemical structure of BindingDB Monomer ID 259337BDBM259337(US9505745, 14 | US9790212, Example 14)
Affinity DataIC50: 630nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 259337BDBM259337(US9505745, 14 | US9790212, Example 14)
Affinity DataIC50: 630nMAssay Description:Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 259337BDBM259337(US9505745, 14 | US9790212, Example 14)
Affinity DataIC50: 2.00E+3nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 259337BDBM259337(US9505745, 14 | US9790212, Example 14)
Affinity DataIC50: 2.00E+3nMAssay Description:Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
US Patent