BDBM259852 US9505766, 56

SMILES CN1CCN(CC1)C(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N

InChI Key InChIKey=KGXAOYTWHINVLV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 259852   

TargetTyrosine-protein kinase BTK(Human)
University of California

US Patent
LigandPNGBDBM259852(US9505766, 56)
Affinity DataIC50: 230nMT: 2°CAssay Description:Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
University of California

US Patent
LigandPNGBDBM259852(US9505766, 56)
Affinity DataIC50: 660nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src [S345C](Human)
University of California

US Patent
LigandPNGBDBM259852(US9505766, 56)
Affinity DataIC50: 1.20E+3nMpH: 7.4 T: 2°CAssay Description:Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of California

US Patent
LigandPNGBDBM259852(US9505766, 56)
Affinity DataIC50: 5.00E+3nMpH: 7.4 T: 2°CAssay Description:Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
University of California

US Patent
LigandPNGBDBM259852(US9505766, 56)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent