BDBM260507 US9527851, 113::US9527851, example 113

SMILES COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ccnc3[nH]ccc23)n1

InChI Key InChIKey=QZZCHXWNBVIWLJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 260507   

TargetTyrosine-protein kinase JAK1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260507(US9527851, 113 | US9527851, example 113)
Affinity DataIC50: 23nMpH: 7.3 T: 2°CAssay Description:TBDIn vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260507(US9527851, 113 | US9527851, example 113)
Affinity DataIC50: 23nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK1 kinase. The test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260507(US9527851, 113 | US9527851, example 113)
Affinity DataIC50: 178nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM260507(US9527851, 113 | US9527851, example 113)
Affinity DataIC50: 178nMpH: 7.3 T: 2°CAssay Description:In vitro kinase assays described below can be used to determine the activity of a test compound for inhibiting the activity of JAK2 kinase. The test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
US Patent