BDBM261424 1-(4-(4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)phenyl)-4-((4-fluorophenyl)sulfonyl)cyclohexyl)piperazin-1-yl)ethanone, Diastereomer 2::US9708253, 83

SMILES CC(=O)N1CCN(CC1)C1CCC(CC1)(c1ccc(cc1)C(OCc1c(F)cccc1F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1

InChI Key InChIKey=DWTUXXUFLLSHGQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 261424   

TargetNuclear receptor ROR-gamma(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM261424(1-(4-(4-(4-(2-((2,6-difluorobenzyl)oxy)-1,1,1,3,3,...)
Affinity DataIC50: 94nMT: 2°CAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent