BDBM261637 N-(4-(4-methyl-3-((triisopropylsilyl)ethynyl)phenyl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide::US9708279, 14

SMILES CC(C)[Si](C#Cc1cc(ccc1C)-c1csc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)n1)(C(C)C)C(C)C

InChI Key InChIKey=ZPKFDKPOEKKGJL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 261637   

TargetALK tyrosine kinase receptor [L1196M](Human)
UniversitÁ

US Patent
LigandPNGBDBM261637(N-(4-(4-methyl-3-((triisopropylsilyl)ethynyl)pheny...)
Affinity DataIC50: 710nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent

TargetALK tyrosine kinase receptor(Human)
UniversitÁ

US Patent
LigandPNGBDBM261637(N-(4-(4-methyl-3-((triisopropylsilyl)ethynyl)pheny...)
Affinity DataIC50: 1.30E+3nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
US Patent