BDBM261980 6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- dimethyl-1H-pyrazol-4-yl)-2- oxo-3,4-dihydropyrido[4,3- d]pyrimidin-1(2H)- yl)nicotinonitrile::US10251892, Example 79::US10632126, Example 79::US11173162, Example 79::US9708318, 79

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3N(C2=O)c2ccc(cn2)C#N)-c2cn(C)nc2C)c1F

InChI Key InChIKey=YJOLFMNETYDKSM-UHFFFAOYSA-N

Data  16 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 261980   

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 3(Human)
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US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 3(Human)
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US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 4(Human)
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US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 1(Human)
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US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/21/2020
Entry Details
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TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2021
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/10/2021
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/21/2020
Entry Details
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TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent

LigandBDBM261980(6-(3-(2,6-difluoro-3,5- dimethoxyphenyl)-7-(1,3- d...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/3/2022
Entry Details
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