BDBM262045 2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methyl- 1-(1-methylpyrrolidin-3-yl)-1H- pyrazol-4-yl)-1'H- spiro[cyclopropane-1,4'- [2,7]naphthyridin]-3'(2'H)-one::US10251892, Example 163::US10632126, Example 163::US11173162, Example 163::US9708318, 163

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(cc3C3(CC3)C2=O)-c2cn(nc2C)C2CCN(C)C2)c1F

InChI Key InChIKey=QIEBARONIFSHFN-UHFFFAOYSA-N

Data  16 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 262045   

TargetFibroblast growth factor receptor 2(Human)
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US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

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Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 2(Human)
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LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 3(Human)
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US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 3(Human)
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US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 3(Human)
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US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 2(Human)
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US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/21/2020
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TargetFibroblast growth factor receptor 3(Human)
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US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 2(Human)
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LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 1(Human)
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US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/31/2018
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TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 1(Human)
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US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 4(Human)
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US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
1/10/2021
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TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
4/3/2022
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TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/21/2020
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:FGFR1, FGFR2, and FGFR4 are measured under equivalent conditions with the following changes in enzyme and ATP concentrations: FGFR1, 0.02 nM and 210 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/31/2018
Entry Details
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TargetFibroblast growth factor receptor 4(Human)
Incyte

US Patent

LigandBDBM262045(2'-(2,6-difluoro-3,5- dimethoxyphenyl)-6'-(3-methy...)Copy SMILESCopy InChI

Affinity DataIC50: 115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/21/2020
Entry Details
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