BDBM263213 1-[4-(2-oxo-2h-pyridin-1-ylmethyl)-benzyl]-3-trifluoromethyl-1h-pyrazole-4-carboxylic acid (4,6-dimethyl-1h-pyrrolo[2,3-b]pyridin-5-ylmethyl)-amide::US9533987, example 8

SMILES Cc1nc2[nH]ccc2c(C)c1CNC(=O)c1cn(Cc2ccc(Cn3ccccc3=O)cc2)nc1C(F)(F)F

InChI Key InChIKey=ZXPGXTZEIVIBIC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 263213   

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263213(US9533987, example 8 | 1-[4-(2-oxo-2h-pyridin-1-yl...)
Affinity DataIC50: 3.72nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263213(US9533987, example 8 | 1-[4-(2-oxo-2h-pyridin-1-yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2018
Entry Details
US Patent