BDBM263285 1-[6-((r)-2-methyl-pyrrolidin-1-yl)-pyridin-3-ylmethyl]-3-trifluoromethyl-1h-pyrazole-4-carboxylic acid (1-amino-isoquinolin-6-ylmethyl)-amide::US9533987, example 63

SMILES C[C@@H]1CCCN1c1ccc(Cn2cc(C(=O)NCc3ccc4c(N)nccc4c3)c(n2)C(F)(F)F)cn1

InChI Key InChIKey=DSSWHEZOLVGIOD-MRXNPFEDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 263285   

TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263285(1-[6-((r)-2-methyl-pyrrolidin-1-yl)-pyridin-3-ylme...)
Affinity DataIC50:  5.70E+3nMAssay Description:Human serine protease enzymes plasmin, thrombin, trypsin, Factor Xa and Factor XIIa were assayed for enzymatic activity using an appropriate fluoroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM263285(1-[6-((r)-2-methyl-pyrrolidin-1-yl)-pyridin-3-ylme...)
Affinity DataIC50:  12.3nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent