BDBM263556 3-(4-{5-amino-4-[5-(4-methyl- piperazine-1-carbonyl)-1h- indole-2-carbonyl]-pyrazol-1-yl}- 3-chloro-phenoxy)-benzonitrile hydrochloride salt::US9556150, i-44

SMILES CN1CCN(CC1)C(=O)c1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc(Oc2cccc(c2)C#N)cc1Cl

InChI Key InChIKey=GHJUACITAOALSI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 263556   

TargetTyrosine-protein kinase BTK(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM263556(3-(4-{5-amino-4-[5-(4-methyl- piperazine-1-carbony...)
Affinity DataIC50: 8nMpH: 7.15Assay Description:This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (F rster/Fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2018
Entry Details
US Patent