BDBM263706 6-(2- chloro-4- ethoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 43

SMILES CCOc1ccc(C2=C(c3ccc(O[C@H]4CCN(CCCF)C4)cc3)c3ccc(O)cc3CCC2)c(Cl)c1

InChI Key InChIKey=FNWAKSQJQUEYND-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 263706   

TargetEstrogen receptor(Human)
Sanofi

US Patent
LigandChemical structure of BindingDB Monomer ID 263706BDBM263706(6-(2- chloro-4- ethoxy- phenyl)-5- [4-[(3S)-1- (3-...)
Affinity DataIC50: 0.800nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetEstrogen receptor [Y537S](Human)
Sanofi

US Patent
LigandChemical structure of BindingDB Monomer ID 263706BDBM263706(6-(2- chloro-4- ethoxy- phenyl)-5- [4-[(3S)-1- (3-...)
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetEstrogen receptor [D538G](Human)
Sanofi

US Patent
LigandChemical structure of BindingDB Monomer ID 263706BDBM263706(6-(2- chloro-4- ethoxy- phenyl)-5- [4-[(3S)-1- (3-...)
Affinity DataIC50: 14nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent