BDBM26373 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[3-(trifluoromethyl)benzene]benzene-1,3-dicarboxamide::CHEMBL259247::unsubstituted pyrimidine amide, 37

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cncnc1

InChI Key InChIKey=MDBBPOZQZACUGK-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 26373   

LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 14nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 14nMAssay Description:Inhibition of c-kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 199nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 200nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 239nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 240nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 240nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 240nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 8.30E+3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 8.33E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 2.50E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM26373(CHEMBL259247 | 4-methyl-3-N-(pyrimidin-5-yl)-1-N-[...)
Affinity DataIC50: 2.50E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed