BDBM263917 6-(2-chloro-4-fluoro-phenyl)-1-fluoro-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid::US9714221, Example 213

SMILES O=C(O)c1ccc2c(c1F)CCCC(c1ccc(F)cc1Cl)=C2c1ccc(O[C@H]2CCN(CCCF)C2)cc1

InChI Key InChIKey=JFOUTGXFUZCZJI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 263917   

TargetEstrogen receptor(Human)
Sanofi

US Patent
LigandChemical structure of BindingDB Monomer ID 263917BDBM263917(6-(2-chloro-4-fluoro-phenyl)-1-fluoro-5-[4-[(3S)-1...)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetEstrogen receptor [Y537S](Human)
Sanofi

US Patent
LigandChemical structure of BindingDB Monomer ID 263917BDBM263917(6-(2-chloro-4-fluoro-phenyl)-1-fluoro-5-[4-[(3S)-1...)
Affinity DataIC50: 23nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetEstrogen receptor [D538G](Human)
Sanofi

US Patent
LigandChemical structure of BindingDB Monomer ID 263917BDBM263917(6-(2-chloro-4-fluoro-phenyl)-1-fluoro-5-[4-[(3S)-1...)
Affinity DataIC50: 39nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent