BDBM264135 2-(3-Bromo-2-methylphenyl)-5-methoxy-1H-pyrido[1,2-c]pyrimidine-1,3(2H)-dione::US9714234, 10

SMILES COc1cccn2c1cc(=O)n(-c1cccc(Br)c1C)c2=O

InChI Key InChIKey=ZQZVWFHQGGQVBY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 264135   

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM264135(2-(3-Bromo-2-methylphenyl)-5-methoxy-1H-pyrido[1,2...)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, INVITROGEN Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM264135(2-(3-Bromo-2-methylphenyl)-5-methoxy-1H-pyrido[1,2...)
Affinity DataIC50: 1.10E+3nMpH: 7.4 T: 2°CAssay Description:Compounds with activity against Jak2 tyrosine kinase have been observed to cause thrombocytopenia, anemia and neutropenia in human patients in clinic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent