BDBM264148 4-Bromo-7-(2-hydroxypropan-2-yl)-8-methyl-9H-carbazole-1-carboxamide::US9714234, 23

SMILES Cc1cc(c(C)c2[nH]c3c(ccc(Br)c3c12)C(N)=O)C(C)(C)O

InChI Key InChIKey=RMPOGHOFLWITKU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 264148   

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM264148(4-Bromo-7-(2-hydroxypropan-2-yl)-8-methyl-9H-carba...)
Affinity DataIC50: 1.20nMpH: 7.4 T: 2°CAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, INVITROGEN Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM264148(4-Bromo-7-(2-hydroxypropan-2-yl)-8-methyl-9H-carba...)
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Compounds with activity against Jak2 tyrosine kinase have been observed to cause thrombocytopenia, anemia and neutropenia in human patients in clinic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent