BDBM264450 6-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(2-methoxypyridin-3-yl)-3-methyl-5,6-dihydropyrrolo[3,4-c]pyrazol-4(2H)-one::US9714249, 17b::US9714249, 25

SMILES COc1ncccc1-n1nc(C)c2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1

InChI Key InChIKey=FLLDFQACNKMSRM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 264450   

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandPNGBDBM264450(US9714249, 25 | 6-(4-chlorophenyl)-5-(1,5-dimethyl...)
Affinity DataIC50: 46nMpH: 7.5Assay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandPNGBDBM264450(US9714249, 25 | 6-(4-chlorophenyl)-5-(1,5-dimethyl...)
Affinity DataIC50: 53nMpH: 7.5Assay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandPNGBDBM264450(US9714249, 25 | 6-(4-chlorophenyl)-5-(1,5-dimethyl...)
Affinity DataIC50: 56nMpH: 7.5Assay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandPNGBDBM264450(US9714249, 25 | 6-(4-chlorophenyl)-5-(1,5-dimethyl...)
Affinity DataIC50: 64nMpH: 7.5Assay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandPNGBDBM264450(US9714249, 25 | 6-(4-chlorophenyl)-5-(1,5-dimethyl...)
Affinity DataIC50: 130nMpH: 7.5Assay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandPNGBDBM264450(US9714249, 25 | 6-(4-chlorophenyl)-5-(1,5-dimethyl...)
Affinity DataIC50: 150nMpH: 7.5Assay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandPNGBDBM264450(US9714249, 25 | 6-(4-chlorophenyl)-5-(1,5-dimethyl...)
Affinity DataIC50: 1.30E+3nMpH: 7.5 T: 2°CAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandPNGBDBM264450(US9714249, 25 | 6-(4-chlorophenyl)-5-(1,5-dimethyl...)
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent