BDBM264520 4-[2'-({(7R)-7-[3,5- bis(trifluoromethyl)phenyl]- 5-oxo-6-oxa-4- azaspiro[2.4]hept-4- yl}methyl)-2-methoxy-6'- (trifluoromethyl)-3,3'- bipyridin-5-yl]-3- methylbenzoic acid::US9717714, 4

SMILES COc1ncc(cc1-c1ccc(nc1CN1C(=O)O[C@H](c2cc(cc(c2)C(F)(F)F)C(F)(F)F)C11CC1)C(F)(F)F)-c1ccc(cc1C)C(O)=O

InChI Key InChIKey=FJEPMZOZMUNBPT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 264520   

TargetCholesteryl ester transfer protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM264520(4-[2'-({(7R)-7-[3,5- bis(trifluoromethyl)phenyl]- ...)
Affinity DataIC50: 173nMAssay Description:Transfer assays are performed in a 96-well v-bottom polypropylene plate. For the RTA using recombinant CETP (2% RTA), an assay cocktail is prepared w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent