BDBM264522 (8R)-8-[3,5- bis(trifluoromethyl)phenyl]-5- ({2-(3-fluoroazetidin-1-yl)-5- [4'-(hydroxymethyl)-4- methoxy-2'-methylbiphenyl-3- yl]pyrimidin-4-yl}methyl)-7- oxa-5-azaspiro[3.4]octan-6-one::US9717714, 7

SMILES COc1ccc(cc1-c1cnc(nc1CN1C(=O)O[C@H](c2cc(cc(c2)C(F)(F)F)C(F)(F)F)C11CCC1)N1CC(F)C1)-c1ccc(CO)cc1C

InChI Key InChIKey=SEEVDVWDMJSSDQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 264522   

TargetCholesteryl ester transfer protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM264522((8R)-8-[3,5- bis(trifluoromethyl)phenyl]-5- ({2-(3...)
Affinity DataIC50: 68nMAssay Description:Transfer assays are performed in a 96-well v-bottom polypropylene plate. For the RTA using recombinant CETP (2% RTA), an assay cocktail is prepared w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent