BDBM264524 8-[3,5- bis(trifluoromethyl)phenyl]- 5-({2-(dimethylamino)-5[4- fluoro-2-methoxy-5-(1- methylethyl)phenyl] pyrimidin-4-yl} methyl)-7-oxa-5- azaspiro[3.4]octan-6-one::US9717714, 11

SMILES COc1cc(F)c(cc1-c1cnc(nc1CN1C(=O)OC(c2cc(cc(c2)C(F)(F)F)C(F)(F)F)C11CCC1)N(C)C)C(C)C

InChI Key InChIKey=DHOMHNAXQHJMFN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 264524   

TargetCholesteryl ester transfer protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM264524(8-[3,5- bis(trifluoromethyl)phenyl]- 5-({2-(dimeth...)
Affinity DataIC50: 318nMAssay Description:Transfer assays are performed in a 96-well v-bottom polypropylene plate. For the RTA using recombinant CETP (2% RTA), an assay cocktail is prepared w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent