BDBM264526 3'-[4-({(8R)-8-[3,5- bis(trifluoromethyl)phenyl]- 6-oxo-7-oxa-5- azaspiro[3.4]oct-5- yl}methyl)-2-morpholin-4- ylpyrimidin-5-yl]-4'- methoxy-2-methylbiphenyl- 4-carboxylic acid::US9717714, 13

SMILES COc1ccc(cc1-c1cnc(nc1CN1C(=O)O[C@H](c2cc(cc(c2)C(F)(F)F)C(F)(F)F)C11CCC1)N1CCOCC1)-c1ccc(cc1C)C(O)=O

InChI Key InChIKey=JFUKOECKEWRDPJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 264526   

TargetCholesteryl ester transfer protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM264526(3'-[4-({(8R)-8-[3,5- bis(trifluoromethyl)phenyl]- ...)
Affinity DataIC50: 242nMAssay Description:Transfer assays are performed in a 96-well v-bottom polypropylene plate. For the RTA using recombinant CETP (2% RTA), an assay cocktail is prepared w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent