BDBM264530 US9717714, 18::methyl 3'-[4-({(7R)-7-[3,5- bis(trifluoromethyl)phenyl]- 5-oxo-6-oxa-4- azaspiro[2.4]hept-4- yl}methyl)-2- (methylsulfanyl)pyrimidin-5- yl]-4'-methoxy-2- methylbiphenyl-4- carboxylate

SMILES COC(=O)c1ccc(c(C)c1)-c1ccc(OC)c(c1)-c1cnc(SC)nc1CN1C(=O)O[C@H](c2cc(cc(c2)C(F)(F)F)C(F)(F)F)C11CC1

InChI Key InChIKey=FHZJNNJYXFRQMD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 264530   

TargetCholesteryl ester transfer protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM264530(methyl 3'-[4-({(7R)-7-[3,5- bis(trifluoromethyl)ph...)
Affinity DataIC50: 596nMAssay Description:Transfer assays are performed in a 96-well v-bottom polypropylene plate. For the RTA using recombinant CETP (2% RTA), an assay cocktail is prepared w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details
US Patent