BDBM267001 (5r,8r)-8-(((6-(1H-tetrazol-1-yl)pyridin-3-yl)methyl)(2-hydroxyethyl)amino)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2-azaspiro[4.5]decan-1-one::US9718808, 130

SMILES CC1=C(COC1=O)N1CC[C@@]2(CC[C@@H](CC2)N(CCO)Cc2ccc(nc2)-n2cnnn2)C1=O

InChI Key InChIKey=YHNQCIRYSHDPBD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 267001   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267001((5r,8r)-8-(((6-(1H-tetrazol-1-yl)pyridin-3-yl)meth...)
Affinity DataIC50: 30nMAssay Description:A Thallium Flux Assay was performed on each of the final product compounds of the Examples. This assay has been described previously; see, e.g., PCT ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent