BDBM26736 CHEMBL509860::LY2183240::N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1H-1,2,3,4-tetrazole-1-carboxamide
SMILES CN(C)C(=O)n1nnnc1Cc1ccc(cc1)-c1ccccc1
InChI Key InChIKey=GZNIYOXWFCDBBJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 26736
Affinity DataIC50: 13nMpH: 7.4 T: 22°CAssay Description:Mouse brain membrane proteomes were preincubated with varying concentrations of inhibitors for 10 min prior to the addition of a rhodamine-tagged flu...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of mouse brain membrane FAAH preincubated for 10 mins followed by 14C-oleamide substrate addition measured up to 60 mins by TLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMpH: 7.4 T: 22°CAssay Description:Serine hydrolase targets were recombinantly expressed in COS-7 cells by transient transfection. IC50 values were obtained by competitive ABPP with F...More data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMpH: 7.4 T: 22°CAssay Description:Serine hydrolase targets were recombinantly expressed in COS-7 cells by transient transfection. IC50 values were obtained by competitive ABPP with F...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of FAAH mediated [14C]anadamide hydrolysis in rat brain after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant DAGLalpha mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in COS cells after 20 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 54.4nMAssay Description:Inhibition of human MGLMore data for this Ligand-Target Pair
Affinity DataIC50: 37.3nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
Affinity DataIC50: 12.4nMAssay Description:Inhibition of rat FAAHMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat brain microsomes assessed as N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide conversion to 4-pyren-1-ylbutanoic ac...More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of human recombinant MAGL-mediated 1,3-dihydroxypropan-1-yl 4-pyren-1-ylbutanoate conversion to 4-pyren-1-ylbutanoic acid preincubated for...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Rat)
Sapienza University of Rome
Curated by ChEMBL
Sapienza University of Rome
Curated by ChEMBL
Affinity DataIC50: 4.94E+4nMAssay Description:Antagonist activity at rat TRPA1 receptor expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced intracellular Ca2+ elevati...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Rat)
Sapienza University of Rome
Curated by ChEMBL
Sapienza University of Rome
Curated by ChEMBL
Affinity DataEC50: 2.69E+4nMAssay Description:Agonist activity at rat TRPA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by spectrofluorimetric anal...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Human)
Sapienza University of Rome
Curated by ChEMBL
Sapienza University of Rome
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Antagonist activity at human TRPV1 receptor expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ elevation incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of FAAH (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 12.4nMAssay Description:Inhibition of rat FAAHMore data for this Ligand-Target Pair
Affinity DataIC50: 38.0nMAssay Description:Inhibition of human recombinant FAAH-maltose binding proteinMore data for this Ligand-Target Pair
Affinity DataIC50: 55.0nMAssay Description:Inhibition of human MGL activity using [3H]2-oleoylglycerol substrate by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMpH: 7.4 T: 22°CAssay Description:Serine hydrolase targets were recombinantly expressed in COS-7 cells by transient transfection. IC50 values were obtained by competitive ABPP with F...More data for this Ligand-Target Pair