BDBM267361 3-chloro-5-((1-((2-(methylamino)-6-oxo-1,6-dihydropyrimidin-5-yl)methyl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile::US10189831, Example 137::US9718819, 137

SMILES CNc1ncc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]1

InChI Key InChIKey=CGZUPRRXFFZKJZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 267361   

TargetGag-Pol polyprotein(HIV-1)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 267361BDBM267361(3-chloro-5-((1-((2-(methylamino)-6-oxo-1,6-dihydro...)
Affinity DataIC50: 9nMAssay Description:The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
US Patent

TargetGag-Pol polyprotein(HIV-1)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 267361BDBM267361(3-chloro-5-((1-((2-(methylamino)-6-oxo-1,6-dihydro...)
Affinity DataIC50: 9nMpH: 7.8 T: 2°CAssay Description:The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2018
Entry Details
US Patent