BDBM26888 8-(diphenylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::CHEMBL240657::spiropiperidine analogue, 9

SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C(c1ccccc1)c1ccccc1

InChI Key InChIKey=MLVHNSLPGKIYBU-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 26888   

TargetNociceptin receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26888(CHEMBL240657 | 8-(diphenylmethyl)-1-phenyl-1,3,8-t...)
Affinity DataKi:  23nM ΔG°:  -10.3kcal/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26888(CHEMBL240657 | 8-(diphenylmethyl)-1-phenyl-1,3,8-t...)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM26888(CHEMBL240657 | 8-(diphenylmethyl)-1-phenyl-1,3,8-t...)
Affinity DataKi:  137nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM26888(CHEMBL240657 | 8-(diphenylmethyl)-1-phenyl-1,3,8-t...)
Affinity DataKi:  137nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM26888(CHEMBL240657 | 8-(diphenylmethyl)-1-phenyl-1,3,8-t...)
Affinity DataKi:  486nMAssay Description:Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM26888(CHEMBL240657 | 8-(diphenylmethyl)-1-phenyl-1,3,8-t...)
Affinity DataKi:  489nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26888(CHEMBL240657 | 8-(diphenylmethyl)-1-phenyl-1,3,8-t...)
Affinity DataKi:  3.79E+4nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26888(CHEMBL240657 | 8-(diphenylmethyl)-1-phenyl-1,3,8-t...)
Affinity DataKi:  3.79E+4nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed