BDBM268982 US9718825, Example 418

SMILES CCN1CCCC(Oc2nc(-c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3)nc3[nH]nc(C)c23)C1

InChI Key InChIKey=WAMFAYLRGUNDRI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 268982   

TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi R&D

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 268982BDBM268982(US9718825, Example 418)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi R&D

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 268982BDBM268982(US9718825, Example 418)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Sanofi R&D

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 268982BDBM268982(US9718825, Example 418)
Affinity DataIC50: 40nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details
US Patent