BDBM26919 8-[(2,6-dichlorophenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::CHEMBL240215::spiropiperidine analogue, 40

SMILES Clc1cccc(Cl)c1CN1CCC2(CC1)N(CNC2=O)c1ccccc1

InChI Key InChIKey=KEDOVCNKPNVSAY-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 26919   

TargetNociceptin receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26919(CHEMBL240215 | 8-[(2,6-dichlorophenyl)methyl]-1-ph...)
Affinity DataKi:  2.30nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26919(CHEMBL240215 | 8-[(2,6-dichlorophenyl)methyl]-1-ph...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26919(CHEMBL240215 | 8-[(2,6-dichlorophenyl)methyl]-1-ph...)
Affinity DataKi:  29nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Schering-Plough Research Institute

LigandPNGBDBM26919(CHEMBL240215 | 8-[(2,6-dichlorophenyl)methyl]-1-ph...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM26919(CHEMBL240215 | 8-[(2,6-dichlorophenyl)methyl]-1-ph...)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM26919(CHEMBL240215 | 8-[(2,6-dichlorophenyl)methyl]-1-ph...)
Affinity DataKi:  52nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM26919(CHEMBL240215 | 8-[(2,6-dichlorophenyl)methyl]-1-ph...)
Affinity DataKi:  1.63E+3nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM26919(CHEMBL240215 | 8-[(2,6-dichlorophenyl)methyl]-1-ph...)
Affinity DataKi:  1.63E+3nMAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2009
Entry Details Article
PubMed