BDBM269748 (R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxypyridin-2-yl)-4H-1,2,4-triazol-3-yl)-2-(4-fluoro-2-(methylsulfonyl)phenyl)-2-hydroxyethanesulfonamide or (S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxypyridin-2-yl)-4H-1,2,4-triazol-3-yl)-2-(4-fluoro-2-(methylsulfonyl)phenyl)-2-hydroxyethanesulfonamide::US10058550, Example 268.0::US10221162, Example 269.0::US9845310, Example 269.0

SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2ccc(F)cc2S(C)(=O)=O)n1-c1c(OC)cccc1OC

InChI Key InChIKey=TZOLDNGTDLWSSY-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 269748   

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269748((R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxypy...)
Affinity DataEC50:  0.170nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269748((R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxypy...)
Affinity DataEC50:  0.170nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269748((R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxypy...)
Affinity DataEC50:  0.170nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269748((R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxypy...)
Affinity DataEC50:  0.350nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269748((R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxypy...)
Affinity DataEC50:  0.350nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
US Patent