BDBM270096 (2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(methylamino)-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-1-(5-fluoro-2-pyrimidinyl)-2-propanesulfonamide, (2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(methylamino)-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-1-(5-fluoro-2-pyrimidinyl)-2-propanesulfonamide::US10058550, Example 662.0::US10058550, Example 663.0

SMILES CNc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC

InChI Key InChIKey=JMTFJSXOLLOTRQ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 270096   

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM270096(US10058550, Example 663.0 | (2R)-N-(4-(2,6-dimetho...)
Affinity DataEC50:  0.180nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM270096(US10058550, Example 663.0 | (2R)-N-(4-(2,6-dimetho...)
Affinity DataEC50:  0.820nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent