BDBM27010 ketoamide derived macrocyclic inhibitor, 34::tert-butyl N-[(3S,11S,14S,15R,17S)-11-(carbamoylcarbonyl)-16,16-dimethyl-2,13-dioxo-1,12-diazatricyclo[12.4.0.0^{15,17}]octadecan-3-yl]carbamate

SMILES CC(C)(C)OC(=O)N[C@H]1CCCCCCC[C@H](NC(=O)[C@@H]2[C@@H]3[C@H](CN2C1=O)C3(C)C)C(=O)C(N)=O

InChI Key InChIKey=AHRRMVANZSRVAL-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27010   

TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM27010(tert-butyl N-[(3S,11S,14S,15R,17S)-11-(carbamoylca...)
Affinity DataKi:  210nM ΔG°:  -9.26kcal/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2009
Entry Details Article
PubMed