BDBM270218 (2S,3R)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-difluorophenyl)-5-(6-methoxy-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-2-butanesulfonamide::US10058550, Example 786.0::US10221162, Example 786.0::US9845310, Example 786.0

SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1-c1c(F)cccc1F

InChI Key InChIKey=GEMWPBUKCCPYSB-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 270218   

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM270218((2S,3R)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-diflu...)
Affinity DataEC50:  0.160nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM270218((2S,3R)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-diflu...)
Affinity DataEC50:  0.160nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM270218((2S,3R)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-diflu...)
Affinity DataEC50:  0.160nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent