BDBM27050 Macrocyclic Peptidomimetic, 18::tert-butyl N-[(3R,13S,16S,17R,19S)-13-[(cyclopropylcarbamoyl)carbonyl]-18,18-dimethyl-2,5,5,15-tetraoxo-5-thia-1,14-diazatricyclo[14.4.0.0^{17,19}]icosan-3-yl]carbamate

SMILES CC(C)(C)OC(=O)N[C@H]1CS(=O)(=O)CCCCCCC[C@H](NC(=O)[C@@H]2[C@@H]3[C@H](CN2C1=O)C3(C)C)C(=O)C(=O)NC1CC1

InChI Key InChIKey=MYCTXMBELKUGGN-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 27050   

TargetGenome polyprotein(HCV)
Schering-Plough Research Institute

LigandPNGBDBM27050(tert-butyl N-[(3R,13S,16S,17R,19S)-13-[(cyclopropy...)
Affinity DataKi:  670nM ΔG°:  -8.56kcal/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2009
Entry Details Article
PubMed