BDBM270538 US10059688, Example 4::US9783524, Example 4

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)C(N)=O)n1)N1CCC(CC1)N(C)C

InChI Key InChIKey=AMSONZZHZCNUHV-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 270538   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270538(US10059688, Example 4 | US9783524, Example 4)
Affinity DataIC50: 4.08nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270538(US10059688, Example 4 | US9783524, Example 4)
Affinity DataIC50: 4.08nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270538(US10059688, Example 4 | US9783524, Example 4)
Affinity DataIC50: 7.52nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270538(US10059688, Example 4 | US9783524, Example 4)
Affinity DataIC50: 7.52nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetALK tyrosine kinase receptor(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270538(US10059688, Example 4 | US9783524, Example 4)
Affinity DataIC50: 27.9nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514) 1. 2.5 uL-4x Test Compound or 100 nL 100x plus 2.4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetALK tyrosine kinase receptor(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270538(US10059688, Example 4 | US9783524, Example 4)
Affinity DataIC50: 28nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270538(US10059688, Example 4 | US9783524, Example 4)
Affinity DataIC50: 44nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270538(US10059688, Example 4 | US9783524, Example 4)
Affinity DataIC50: 44.3nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270538(US10059688, Example 4 | US9783524, Example 4)
Affinity DataIC50: 45nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM270538(US10059688, Example 4 | US9783524, Example 4)
Affinity DataIC50: 45.1nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent