BDBM270579 (R)-4-((8-chloro-6- (((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4- yl)(4- fluorophenyl)methyl- d)amino)quinazolin- 4-yl)amino)-4- phenylbutanenitrile::US10059695, I-11::US10577352, Compound I-11

SMILES Fc1ccc(cc1)C(Nc1cc(Cl)c2ncnc(N[C@H](CCC#N)c3ccccc3)c2c1)c1cn(nn1)C1CC1

InChI Key InChIKey=LMGXIJOACLYHHX-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270579   

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270579((R)-4-((8-chloro-6- (((S)-(1-cyclopropyl- 1H-1,2,3...)
Affinity DataIC50: 46nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270579((R)-4-((8-chloro-6- (((S)-(1-cyclopropyl- 1H-1,2,3...)
Affinity DataIC50: 46nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270579((R)-4-((8-chloro-6- (((S)-(1-cyclopropyl- 1H-1,2,3...)
Affinity DataEC50:  671nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270579((R)-4-((8-chloro-6- (((S)-(1-cyclopropyl- 1H-1,2,3...)
Affinity DataEC50:  671nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent