BDBM270597 8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((1-(1- ethylpiperidin-4-yl)- 1H-1,2,3-triazol-4- yl)(phenyl)methyl) quinazoline-4,6- diamine::US10059695, II-3::US10577352, Compound II-3

SMILES CCN1CCC(CC1)n1cc(nn1)C(Nc1cc(Cl)c2ncnc(Nc3ccc(F)c(Cl)c3)c2c1)c1ccccc1

InChI Key InChIKey=BGNGGPVTCBTSPQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 270597   

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270597(8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((1-(1...)
Affinity DataIC50: 19nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM270597(8-chloro-N4-(3- chloro-4- fluorophenyl)-N6- ((1-(1...)
Affinity DataIC50: 19nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent