BDBM27215 (1R,2S,5S,9R,12S,13R,16S)-16-(dimethylamino)-7,13-dimethyl-7-azapentacyclo[10.8.0.0^{2,9}.0^{5,9}.0^{13,18}]icos-18-en-6-one::Conessine analogue, 10

SMILES [H][C@]12CC[C@@]3([H])[C@]4([H])CC=C5C[C@H](CC[C@]5(C)[C@@]4([H])CC[C@]13CN(C)C2=O)N(C)C

InChI Key InChIKey=PQSIXDAWRTXGGA-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 27215   

TargetHistamine H3 receptor(Human)
Abbott Laboratories

LigandPNGBDBM27215((1R,2S,5S,9R,12S,13R,16S)-16-(dimethylamino)-7,13-...)
Affinity DataKi:  543nM ΔG°:  -8.54kcal/molepH: 7.4 T: 2°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Abbott Laboratories

LigandPNGBDBM27215((1R,2S,5S,9R,12S,13R,16S)-16-(dimethylamino)-7,13-...)
Affinity DataKi:  543nMAssay Description:Displacement of [3H]N-alpha methyl histamine from human cloned histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM27215((1R,2S,5S,9R,12S,13R,16S)-16-(dimethylamino)-7,13-...)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]N-alpha methyl histamine from rat cortical membrane histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM27215((1R,2S,5S,9R,12S,13R,16S)-16-(dimethylamino)-7,13-...)
Affinity DataKi:  1.00E+3nMAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed