BDBM27218 (2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)pyrazolo[1,5-a][1,3,5]triazin-2-yl}amino)-3-methylbutan-1-ol::pyrazolo[1,5-a]-1,3,5-triazine, 7c

SMILES CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)n2ncc(C(C)C)c2n1

InChI Key InChIKey=XCRSLBLUJPTVDN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 27218   

LigandPNGBDBM27218((2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)...)
Affinity DataIC50: 80nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Universite De Lyon

LigandPNGBDBM27218((2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)...)
Affinity DataIC50: 60nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Human)
Universite De Lyon

LigandPNGBDBM27218((2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)...)
Affinity DataIC50: 60nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Universite De Lyon

LigandPNGBDBM27218((2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Universite De Lyon

LigandPNGBDBM27218((2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2009
Entry Details Article
PubMed