BDBM272565 (R)-3-(ethylamino)-6-(1-phenylethyl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one::US10065967, Example 29::US10759805, Ex 29

SMILES CCNc1n[nH]c2cc3NC(=O)N(Cc3cc12)[C@H](C)c1ccccc1

InChI Key InChIKey=GDUDOXLXOIQPST-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 272565   

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM272565((R)-3-(ethylamino)-6-(1-phenylethyl)-5,6-dihydro-1...)
Affinity DataIC50: 22nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM272565((R)-3-(ethylamino)-6-(1-phenylethyl)-5,6-dihydro-1...)
Affinity DataIC50: 2.20E+4nMAssay Description:Human: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2021
Entry Details
US Patent