BDBM272737 2-Amino-N-[1-(8-chloro-5-pyrazin-2- ylimidazo[1,5-a]pyridin-6-yl)ethyl]pyrazolo[1,5- a]pyrimidine-3-carboxamide trifluoroacetate salt (racemic mixture prepared)::US10065963, Example 138

SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1cnccn1

InChI Key InChIKey=DWDAMYYZDHIIET-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 272737   

LigandPNGBDBM272737(2-Amino-N-[1-(8-chloro-5-pyrazin-2- ylimidazo[1,5-...)
Affinity DataIC50: 100nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

LigandPNGBDBM272737(2-Amino-N-[1-(8-chloro-5-pyrazin-2- ylimidazo[1,5-...)
Affinity DataIC50: 500nMpH: 6.7 T: 2°CAssay Description:[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

LigandPNGBDBM272737(2-Amino-N-[1-(8-chloro-5-pyrazin-2- ylimidazo[1,5-...)
Affinity DataIC50: 1.00E+3nMAssay Description:To measure the Phosphorylated Ribosomal Protein S6 (RPS6) in cell lysates, THP-1 cells (Human Acute Monocytic Leukemia) are purchased from ATCC (Mana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent